Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. How should I take Diovan HCT hydrochlorothiazide and valsartan? Kg weight not to exceed 40 mg per day. Diovan is not recommended for children under the age of 6 or in children with certain renal problems. Diovan may interact with cyclosporine, water pills rifampin, ritonavir, or nonsteroidal anti-inflammatory drugs . Tell your doctor all medications and supplements you use. Magil AB "Drug-induced acute interstitial nephritis with granulomas.
Here are common types of medication that can make worse. In rare cases, valsartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Diffey BL, Langtry J "Phototoxic potential of thiazide diuretics in normal subjects. At the bottom of the page under Herbal Therapies for High Blood Pressure it does state, "The efficacy and safety of herbal therapies, such as Rauwolfia serpentina snakeroot Stephania tetrandra tetrandrine Panax notoginseng ginseng and Crataegus species hawthorn for treating high blood pressure have not been extensively studied. Because of potential health risks associated with these herbs, it is imperative that you inform your doctor if you plan to use or are already using them. This is even more important if these herbs are used in combination with high blood pressure drugs.
Since HCTZ may increase total serum cholesterol by 11%, LDL lipoprotein cholesterol by 12%, and VLDL lipoprotein cholesterol levels by 50%, and may reduce insulin secretion, it should be used with caution in diabetic patients and in those with hypercholesterolemia. True glucose intolerance may develop in approximately 3% of patients. It is typically reversible within six months after discontinuation of therapy. If your symptoms do not improve or if they become worse, check with your doctor. Dizziness or lightheadedness may occur as your body adjusts to the medication. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly.
Irons BK, Kumar A "Valsartan-induced angioedema. If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns. Check your regularly while taking this medication. Learn how to monitor your own pressure, and share the results with your doctor. Side Effects List Diovan side effects by likelihood and severity. Do not store in the bathroom. Keep all medications away from children and pets.
If you also take certain drugs to lower your cholesterol bile acid-binding resins such as cholestyramine or colestipol take this product at least 4 hours before or at least 4 to 6 hours after these medications. Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and valsartan. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal. Jones IG, Pickens PT "Diabetes mellitus following oral diuretics. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Valsartan is an angiotensin receptor blocker ARB and works by relaxing vessels so that can flow more easily. Hydrochlorothiazide is a "water pill" that causes you to make more urine, which helps your body get rid of extra salt and water. Some drugs work by tightening vessels in your head. This relieves pain. However, the medication also constricts blood vessels throughout your body. This can make blood pressure rise, perhaps to dangerous levels. Take this medication by with or without food as directed by your doctor, usually once daily. If this medication causes you to urinate more frequently, it is best to take it at least 4 hours before your to prevent having to get up to urinate. Fine SR, Lodha A, Zoneraich S, Mollura JL "Thiazide-induced pulmonary edema. Lab tests, including blood pressure, blood electrolyte levels, heart function, and kidney function, may be performed while you use Diovan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Keep all medical and lab appointments. PREGNANCY and BREAST-FEEDING: Diovan HCT may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Diovan HCT is found in breast milk. Do not breast-feed while taking Diovan HCT. If you miss a dose of Diovan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Do not use valsartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective while taking valsartan. Severe allergic reactions rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; blurred vision; burning, numbness, or tingling; change in the amount of urine produced; chest pain; difficulty swallowing; fainting; irregular heartbeat; muscle pain, weakness, or cramps; shortness of breath; sudden, unexplained weight gain; swelling of the hands, ankles, or feet; symptoms of liver problems eg, dark urine, loss of appetite, pale stools, severe or persistent stomach pain, yellowing of the eyes or skin; symptoms of low blood pressure eg, fainting, light-headedness, severe dizziness; unusual bruising or bleeding.
Use of valsartan alone has not been associated with significant changes in serum lipids or glucose concentrations. However, use of HCTZ may be associated with increases in total serum cholesterol by 11%, LDL lipoprotein cholesterol by 12%, and VLDL lipoprotein cholesterol levels by 50%. In addition, use of HCTZ may be associated with reduced insulin secretion. Therefore, caution is recommended when giving this combination drug to diabetic patients or those with hypercholesterolemia. About 93% of patients received concomitant ACE inhibitors. Those studies were based on patients' medical records, not direct tests of the drugs. So Pasinetti's team headed to their lab to do some experiments. This medication may interfere with certain laboratory tests including parathyroid function possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Prupas HM, Brown D "Acute idiosyncratic reaction to hydrochlorothiazide ingestion. You may take hydrochlorothiazide and valsartan with or without food. Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and valsartan. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. If you cannot swallow capsules or tablets, ask your doctor or pharmacist about preparing a suspension of Diovan. Use Diovan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Pasinetti and colleagues pitted 55 drugs against beta-amyloid proteins in test tubes. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose. Take your next dose at the regular time. That is your best plan by far! Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure, and share the results with your doctor. NOS, nausea, renal impairment NOS, syncope, blurred vision, upper abdominal pain and vertigo. Holland GW "Stenosing ulcers of the small bowel associated with thiazide and potassium therapy. Bjornberg A, Gisslen H "Thiazides: A cause of necrotising vasculitis? This product may affect your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Decongestants may prevent high from working properly. Harper R, Ennis CN, Heaney AP, Sheridan B, Gormley M, Atkinson AB, Johnston GD, Bell PM "A comparison of the effects of low- and conventional-dose thiazide diuretic on insulin action in hypertensive patients with NIDDM. Frye CB, Pettigrew TJ "Angioedema and photosensitive rash induced by valsartan. Drinking alcohol can further lower your blood pressure and may increase certain side effects of valsartan. Ask your health care provider any questions you may have about how to use Diovan HCT. Side Effects List Diovan HCT side effects by likelihood and severity.
Some of the side effects that can occur with valsartan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Bronchospasm, dyspnea, and epistaxis have rarely been associated with the use of this drug. Diovan HCT contains a sulfonamide called hydrochlorothiazide, which can cause certain eye problems myopia, angle-closure glaucoma. Your risk may be increased if you are allergic to sulfonamide medicines eg, sulfamethoxazole or to penicillin antibiotics eg, amoxicillin. Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting Diovan HCT. Contact your doctor right away if you experience symptoms such as vision changes eg, decreased vision clearness or eye pain. This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Reed BR, Huff JC, Jones SK, Orton PW, Lee LA, Norris DA "Subacute cutaneous lupus erythematosus associated with hydrochlorothiazide therapy. Older adults may be more sensitive to the side effects of this drug, especially dizziness and change in the amount of urine kidney problems. Their study appears in The Journal of Clinical Investigation. Weir MR, Wright JT, Jr Ferdinand KC, Cook CA, Champion D, Wong S, Jenkins PA, Kong BW "Comparison of the efficacy and metabolic effects of nicardipine and hydrochlorothiazide in hypertensive black men and women. Kasiske BL, Ma JZ, Kalil RS, Louis TA "Effects of antihypertensive therapy on serum lipids. Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own, use a salt substitute, or change your diet to include more potassium without first checking with your doctor. Does Diovan oral have side effects? Garratty G, Houston M, Petz LD, Webb M "Acute immune intravascular hemolysis due to hydrochlorothiazide. Rare cases of have been reported in patients receiving II receptor blockers.
Which drugs or supplements interact with valsartan? What is the most important information I should know about valsartan Diovan? After drinking their assigned water for 11 months, the mice took a memory test in which they had to learn and remember the path through a watery maze. Pollare T, Lithell H, Berne C "A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. Campbell JR, Knapp RW "Small bowel ulceration associated with thiazide and potassium therapy: review of 13 cases. It is not known whether hydrochlorothiazide and valsartan passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Angiotensin II receptor blockade, unlike ACE inhibition, has no impact on the processing of peptides such as bradykinin and substance P, two peptides able to induce cough. An extra patient leaflet is available with Diovan HCT. Talk to your pharmacist if you have questions about this information. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Rosenberg L, Shapiro S, Slone D, Kaufman DW, Miettinen OS, Stolley PD "Thiazides and acute cholecystitis. Holland OB, Kuhnert L, Pollard J, Padia M, Anderson RJ, Blomqvist G "Ventricular ectopic activity with diuretic therapy. Tell your doctor or dentist that you take Diovan before you receive any medical or dental care, emergency care, or surgery.
Do not start, stop, or change the dosage of any medicines without your doctor's approval. Use Diovan HCT as directed by your doctor. Check the label on the medicine for exact dosing instructions. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with not feel sick. Further lab tests showed that one of those seven drugs, Diovan, hindered certain beta-amyloid ingredients. Withdrawal of thiazide therapy for 7 months in 10 of the patients resulted in average reductions of 10% in fasting blood glucose and 25% in 2-hour glucose tolerance test values. A control group was not reported. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition.
Peters RW, Hamilton J, Hamilton BP "Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension. Diamond MT "Hyperglycemic hyperosmolar coma associated with hydrochlorothiazide and pancreatitis. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use and wear protective clothing when outdoors. Avoid using and cold medicine that contains NSAIDs or decongestants. Take this medication by mouth with or without food as directed by your doctor, usually once daily. If this medication causes you to urinate more frequently, it is best to take it at least 4 hours before your bedtime to prevent having to get up to urinate. It may take 2 to 4 weeks for Diovan HCT to work fully. Do not stop using Diovan HCT or change your dose of Diovan HCT without checking with your doctor. Do not stop taking any medications without consulting your healthcare provider. Some of the mice drank water laced with Diovan. Their Diovan dose was lower than that used for people with high blood pressure. Diovan may not work as well in black patients. Discuss any questions or concerns with your doctor. Delevett AF, Recalde M "Diuretic-induced renal colic. But when the researchers tested mice without the gene glitch, Diovan treatment didn't help or hurt the mice navigate the watery maze. Product Information. Diovan valsartan.
Take Diovan HCT by mouth with or without food. Hoss DM, Nierenberg DW "Severe shaking chills and fever following hydrochlorothiazide administration. Read medication labels before buying over-the-counter preparations. Make sure the medicine doesn't contain ingredients that could make your high blood pressure worse, such as NSAIDs or decongestants. Bell DS "Insulin resistance. An often unrecognized problem accompanying chronic medical disorders. The dosage is based on your medical condition and response to treatment. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Flores CA, Ardiles LG, Aros CA, et al. "Valsartan-Induced Hematocrit Changes in Renal Transplant Patients. Wagner W, Longerbeam JK, Smith LL, Feikes HL "Drug-induced ulcers of the small bowel causing intestinal obstruction or perforation. This information should not be used to decide whether or not to take Diovan or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Diovan. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Diovan. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Diovan. Kiykim A, Altintas E, Sezgin O, et al. "Valsartan-induced hepatotoxicity in a HBs-Ag-Positive patient. Mouallem M, Friedman E, Shemesh Y, Mayan H, Pauzner R, Farfel Z "Cardiac conduction defects associated with hyponatremia. Chest pain was reported in more than 2% of patients who were taking this combination drug in controlled trials, but this incidence was not significantly different compared with the incidence of chest pain among placebo patients. Severe sweating, diarrhea, or vomiting can increase the risk for lightheadedness or a serious loss of body water dehydration. Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise. Ask your health care provider any questions you may have about how to use Diovan. Thiazide diuretics may increase serum cholesterol and triglycerides, resulting in an increased risk of cholesterol gallstone formation. Reports of bowel strictures associated with thiazide ingestion were reported in the 1960s although patients in these reports were on a combination HCTZ-potassium product.
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If you have diabetes, this product may affect your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Berlin I "Prazosin, diuretics, and glucose intolerance. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Hydrochlorothiazide and valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control. The mice that drank the Diovan water fared best in the maze test.
Diovan should not be used in CHILDREN younger than 6 years old; safety in these children has not been confirmed. Mahabir RN, Laufer ST "Clinical evaluation of diuretics in congestive heart failure. A detailed study in four patients. Diovan may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness. Symptoms may include fainting; fast or slow heartbeat; severe or unusual dizziness, drowsiness, or light-headedness; symptoms of blood electrolyte problems eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping; seizures; sluggishness; symptoms of dehydration eg, decreased urination; dry mouth or eyes; fast heartbeat; unusual thirst, tiredness, or weakness.
Dietz MW "Iatrogenic jejunal ulcer. Valsartan-associated hepatotoxicity in a patient with hepatitis B surface antigen HBs-Ag positivity without signs and symptoms has been reported. After 1 month of treatment with valsartan the active ingredient contained in Diovan this patient developed pruritic erythematous skin changes, nausea, jaundice, right subcostal abdominal pain, elevated liver enzymes, and mild hepatomegaly. Signs and symptoms of hepatotoxicity resolved within 2 to 3 weeks following discontinuation of valsartan and the patient remained asymptomatic after 6 months of follow-up. Store the suspension at room temperature for up to 30 days, or in the refrigerator for up to 75 days. Do not freeze.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Continue to take Diovan HCT even if you feel well. Do not miss any doses.